Activation of the Anrep Effect in Aortic Stenosis Pre-TAVR and Post-TAVR
In severe AS, the Anrep effect supports output at high energetic cost. TAVR reverses this state, unloading the heart and reducing mechanical demand without altering ejection fraction. This identifies the Anrep as a clinically relevant load-dependent mechanism in AS and highlights its reversibility post-TAVR.
Authors
- Jan M. Federspiel (ORCID: https://orcid.org/0000-0002-9325-2658)
- Volker Rudolph (ORCID: https://orcid.org/0000-0001-5385-6839)
- Werner Scholtz (ORCID: https://orcid.org/0000-0003-0959-0054)
- Philipp Lucas
- Smita Scholtz (ORCID: https://orcid.org/0000-0002-7445-5986)
- Christoph Marquetand (ORCID: https://orcid.org/0000-0002-6279-9239)
- Hazem Omran (ORCID: https://orcid.org/0000-0001-7342-3686)
- Vasco Sequeira (ORCID: https://orcid.org/0000-0002-9192-7674)
- Paul Steendijk (ORCID: https://orcid.org/0000-0002-8454-4499)
- Jan‐Christian Reil (ORCID: https://orcid.org/0000-0003-1053-5175)
- Labib Tadros
- Tanja K. Rudolph (ORCID: https://orcid.org/0000-0001-8839-7476)
- Gert‐Hinrich Reil
- Cornelia Piper
Institutions
- University of Würzburg (DE)
- Leiden University Medical Center (NL)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- Universitäts-Kinderklinik Würzburg (DE)
- Klinikum Oldenburg (DE)
- Saarland University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- JACC Advances
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1016/j.jacadv.2025.102424
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00