Rapamycin preserves cardiac function in autoimmune myocarditis by reprogramming Cxcl9+ macrophages via the mTORC1–C/EBPβ–OSM axis
Rapamycin preserves cardiac function in autoimmune myocarditis by reprogramming Cxcl9<sup>+</sup> macrophages via the mTORC1-C/EBPβ-OSM axis. Targeting OSM provides mechanistic validation and highlights a translational therapeutic strategy for myocarditis and chronic inflammatory cardiomyopathy.
Authors
- Yongcui Yan (ORCID: https://orcid.org/0000-0002-0705-2087)
- Xiaoquan Rao (ORCID: https://orcid.org/0000-0001-7316-4530)
- Huihui Li (ORCID: https://orcid.org/0000-0003-0511-1693)
- Wen Zheng (ORCID: https://orcid.org/0000-0003-4316-2459)
- Yan Zhuang (ORCID: https://orcid.org/0000-0001-7351-377X)
- Jiangang Jiang (ORCID: https://orcid.org/0000-0002-8606-6291)
- Daowen Wang (ORCID: https://orcid.org/0000-0002-6230-8735)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1016/j.redox.2025.103970
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00