Prospective, randomized dose-escalation trial with proton-based radiation for skull base and cervical spine chondrosarcomas: 30-year outcomes from PROG 85-26
This is the first and largest trial of patients with grade I/II BOS and CS CHS evaluating dose escalation for tumor control. Proton-based RT is effective and safe for these tumors, but there is no apparent benefit in dose escalation.
Authors
- G. Petur Nielsen
- Kevin X. Liu (ORCID: https://orcid.org/0000-0003-2071-5137)
- Thomas F. DeLaney (ORCID: https://orcid.org/0000-0002-0346-3487)
- Andrew Rosenberg (ORCID: https://orcid.org/0000-0001-5296-9225)
- Daniel W. Kim (ORCID: https://orcid.org/0000-0003-0625-3466)
- Yin P. Hung (ORCID: https://orcid.org/0000-0002-8568-1591)
- Helen Alice Shih (ORCID: https://orcid.org/0000-0003-1550-9726)
- Fantine Giap (ORCID: https://orcid.org/0000-0003-4039-0392)
- Daniel George Packard (ORCID: https://orcid.org/0000-0002-1390-7221)
- Nicolas Depauw (ORCID: https://orcid.org/0000-0002-0486-6149)
- Shannon M. MacDonald (ORCID: https://orcid.org/0000-0001-9092-1337)
- William T. Curry (ORCID: https://orcid.org/0000-0002-8036-1847)
- Yuh-Shin Chang (ORCID: https://orcid.org/0000-0002-7476-2409)
- Stephen Zieminski
- Athena Tejada
- Mary E. Cunnane (ORCID: https://orcid.org/0000-0002-7133-859X)
- Daniel G. Tobert (ORCID: https://orcid.org/0000-0001-6168-0175)
- Z. Soetan
- Hillary R. Kelly (ORCID: https://orcid.org/0000-0002-6655-8723)
- Myrsini Ioakeim‐Ioannidou
- Yen‐Lin Chen (ORCID: https://orcid.org/0000-0002-6381-4269)
- Paul A. Gardner (ORCID: https://orcid.org/0000-0002-1594-1722)
- Ganesh M. Shankar
- Rana Hegazy
- Gregory M. Coté (ORCID: https://orcid.org/0000-0003-0181-886X)
- Engy S. Todary
- Judith E. Adams
- Eugen B. Hug
- Hanne M. Kooy
- Beow Yong Yeap (ORCID: https://orcid.org/0009-0004-6157-5489)
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Dartmouth–Hitchcock Medical Center (US)
- Tufts Medical Center (US)
- Mayo Clinic (US)
- St. George's University (GD)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Virginia Cancer Institute (US)
- University of Miami Hospital (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- MedAustron (AT)
- Neurological Surgery (US)
- New York University Langone Orthopedic Hospital (US)
- Children Cancer Hospital (EG)
- Mass General Brigham (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1093/neuonc/noaf289
- Citations
- 1
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.67