Proteomic profiling of Alzheimer’s disease and Vascular dementia reveals unique underlying signatures
Findings underscore the importance of APOE genotype and highlight SNAP25, EDA2R, TIMP4, and PVR as potential biomarkers and therapeutic targets.
Authors
- Najaf Amin (ORCID: https://orcid.org/0000-0002-8944-1771)
- Cornelia M. van Duijn (ORCID: https://orcid.org/0000-0002-2374-9204)
- Masud Husain (ORCID: https://orcid.org/0000-0002-6850-9255)
- Sihao Xiao (ORCID: https://orcid.org/0000-0003-1952-6494)
- Pallavi Kaushik (ORCID: https://orcid.org/0000-0003-3566-1418)
- M. Austin Argentieri (ORCID: https://orcid.org/0000-0003-0242-853X)
- Lazaros Belbasis (ORCID: https://orcid.org/0000-0002-2334-6974)
- Shahzad Ahmad (ORCID: https://orcid.org/0000-0002-8658-3790)
- Rima Kaddurah-Daouk
Institutions
- Broad Institute (US)
- Duke University (US)
- University of Oxford (GB)
- Massachusetts General Hospital (US)
- Nuffield Health (GB)
- Institute of Molecular Medicine (IN)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-09
- DOI
- https://doi.org/10.64898/2025.12.08.25341836
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research