Determining optimal GTV‐to‐PGTV margins for CT‐guided dose‐escalated radiotherapy with daily image guidance in locally advanced rectal cancer
A 6 mm isotropic GTV to PGTV margin provides adequate target coverage for most middle- and lower-rectal tumors while reducing OAR overlap. This finding could facilitate safer dose escalation while maintaining target coverage. However, larger margins may be necessary for smaller tumors or those located in the high rectum.
Authors
- Kai Liu (ORCID: https://orcid.org/0000-0003-2285-6822)
- Lecheng Jia
- Yangyi Zhang (ORCID: https://orcid.org/0000-0003-3174-657X)
- Xian‐He Zhao (ORCID: https://orcid.org/0000-0002-1562-4292)
- Ke Hu (ORCID: https://orcid.org/0000-0003-1079-5137)
- Yiming Zhang (ORCID: https://orcid.org/0000-0001-8547-6654)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7800-3189)
- Weiping Wang (ORCID: https://orcid.org/0000-0001-7511-3497)
- Zhaoqi Gu
- Yongguang Liang
- Mengying Yang
- Qi Xi (ORCID: https://orcid.org/0000-0001-6993-3819)
- Chen Wang (ORCID: https://orcid.org/0000-0002-2132-0869)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- United Imaging Healthcare (China) (CN)
Publication Details
- Journal
- Journal of Applied Clinical Medical Physics
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1002/acm2.70429
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology of the People's Republic of China
- Peking Union Medical College Hospital