Decoding neurovascular signatures: advanced imaging insights in DADA2-Related Cerebral Microangiopathy
DADA2 exhibited a profoundly high risk of stroke recurrence, with substantial lesions being clinically asymptomatic, underscoring the importance of routine neuroimaging evaluation for DADA2 patients. This disease presents a unique CSVD phenotype characterized by brainstem-deep gray nucleus ischemic predominance and infratentorial atrophy yet paradoxically low burdens of CMBs and WMH compared to other CSVD. This distinctive imaging triad not only facilitates early recognition and timely intervention, but also suggests a pathophysiological divergence from other CSVD.
Authors
- Jun Ni (ORCID: https://orcid.org/0000-0002-7877-612X)
- Hanhui Fu
- Yaping Zhou (ORCID: https://orcid.org/0000-0003-4398-1403)
- Yicheng Zhu (ORCID: https://orcid.org/0000-0003-3037-0398)
- Nan Jiang (ORCID: https://orcid.org/0000-0001-5287-8593)
- Min Shen (ORCID: https://orcid.org/0000-0003-1912-126X)
- Ming Yao (ORCID: https://orcid.org/0000-0003-2104-3248)
- Fei Han (ORCID: https://orcid.org/0000-0002-2720-392X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Neurological Sciences
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1007/s10072-025-08676-9
- Citations
- 1
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.39