An AIE-active platinum complex for enhanced photodynamic therapy
Conventional photodynamic therapy (PDT) suffers from aggregation-caused quenching and high oxygen dependence. Herein, we report a platinum (Pt)-coordinated photosensitizer (TPAQPt) for hypoxia-tolerant PDT. Inheriting aggregation-induced emission (AIE) features, high spin orbital coupling and intramolecular charge transfer ability, TPAQPt exhibits robust type I reactive oxygen species generation and a promising antitumor PDT effect.
Authors
- Guangxue Feng (ORCID: https://orcid.org/0000-0003-4344-3517)
- Ben Zhong Tang (ORCID: https://orcid.org/0000-0002-0293-964X)
- Wenjing Li (ORCID: https://orcid.org/0000-0002-6321-3199)
- Ping Liang (ORCID: https://orcid.org/0009-0003-1569-1246)
Institutions
- Chinese University of Hong Kong, Shenzhen (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1039/d5cc05324b
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00