Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer
This work provides functional evidence for the causal role of secondary BAs produced by gut bacteria through 7αDH in CRC under adverse dietary conditions, opening avenues for future preventive strategies.
Authors
- Burkhard Kleuser (ORCID: https://orcid.org/0000-0002-1888-9595)
- David Wylensek (ORCID: https://orcid.org/0000-0002-8424-5712)
- Annika Oßwald (ORCID: https://orcid.org/0000-0003-3734-4125)
- Jason M. Ridlon (ORCID: https://orcid.org/0000-0001-5813-099X)
- Wei Liang (ORCID: https://orcid.org/0009-0003-1791-3631)
- Dirk Haller (ORCID: https://orcid.org/0000-0002-6977-4085)
- Esther Wortmann (ORCID: https://orcid.org/0000-0002-0895-113X)
- Georg Zeller (ORCID: https://orcid.org/0000-0003-1429-7485)
- Sebastian Zeißig (ORCID: https://orcid.org/0000-0001-5124-0897)
- Fabian Schumacher (ORCID: https://orcid.org/0000-0001-8703-3275)
- Olivia I. Coleman (ORCID: https://orcid.org/0000-0002-4075-7820)
- Nicole Treichel
- Gerhard Liebisch (ORCID: https://orcid.org/0000-0003-4886-0811)
- Colin Volet (ORCID: https://orcid.org/0000-0003-3546-9602)
- Sascha Rohn (ORCID: https://orcid.org/0000-0002-5009-8830)
- Kenneth Peuker (ORCID: https://orcid.org/0000-0001-8501-429X)
- Michael Gigl (ORCID: https://orcid.org/0000-0002-5617-9236)
- Anne Strigli
- Krzysztof Flisikowski
- Martin Larralde (ORCID: https://orcid.org/0000-0002-3947-4444)
- Angelika Schnieke (ORCID: https://orcid.org/0000-0002-5761-9635)
- Silke Matysik (ORCID: https://orcid.org/0000-0001-8590-8154)
- Soeren Ocvirk (ORCID: https://orcid.org/0000-0001-6547-2445)
- Rizlan Bernier‐Latmani (ORCID: https://orcid.org/0000-0001-6547-722X)
- Stephanie Kuhls
- Thomas Clavel (ORCID: https://orcid.org/0000-0002-7229-5595)
- Quinten R. Ducarmon (ORCID: https://orcid.org/0000-0001-7077-2127)
- Chun‐Jun Guo (ORCID: https://orcid.org/0000-0002-7227-4591)
- Karin Kleigrewe (ORCID: https://orcid.org/0000-0002-7718-0252)
Institutions
- University of Bern (CH)
- University of Illinois Urbana-Champaign (US)
- Cornell University (US)
- Universitätsmedizin Greifswald (DE)
- Leiden University Medical Center (NL)
- University Hospital of Bern (CH)
- University Hospital Regensburg (DE)
- Universitätsklinikum Aachen (DE)
- European Molecular Biology Laboratory (DE)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- German Institute of Human Nutrition (DE)
- Technische Universität Berlin (DE)
- École Polytechnique Fédérale de Lausanne (CH)
- Technical University of Munich (DE)
- Freie Universität Berlin (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Gut
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1136/gutjnl-2024-332243
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Technische Universität München