Sleep effects on brain, cognition, and mental health during adolescence are mediated by the glymphatic system.
Insufficient sleep during adolescence is linked to glymphatic dysfunction, reflected by increased PVS burden, which partially accounts for adverse effects on brain structure, cognition, and mental health. These findings highlight the glymphatic system as a potential mechanistic pathway and imaging biomarker, underscoring the importance of promoting adequate sleep to support neurodevelopment and mental health.
Authors
- Jiachen Zhuo (ORCID: https://orcid.org/0000-0001-6637-701X)
- Gianpaolo Del Mauro (ORCID: https://orcid.org/0000-0003-1982-2875)
- Laura M. Rowland (ORCID: https://orcid.org/0000-0002-6795-4269)
- Fan Yang (ORCID: https://orcid.org/0000-0003-2565-6594)
- Yiran Li (ORCID: https://orcid.org/0000-0002-4658-3876)
- Ze Wang (ORCID: https://orcid.org/0000-0002-8339-5567)
- Ruoxi Lu
- Jiaao Yu (ORCID: https://orcid.org/0000-0002-4665-200X)
- Xinglin Zeng
- Wickwire Emerson
Institutions
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- University of Maryland, College Park (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-12-09
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00