MYSM1 regulates the proliferation and differentiation of bovine skeletal muscle satellite cells via BRG1-mediated activation of the AKT/mTOR/NF-κB signaling pathway
s: MYSM1 promotes the proliferation and differentiation of BSMSCs through BRG1-mediated epigenetic regulation and activation of the AKT/mTOR/NF-κB signaling cascade. These findings establish a dual-target framework that not only advances the understanding of muscle development in beef cattle but also offers potential strategies for regenerative therapies.
Authors
- Chujie Zhang
- Debao Hu
- Xiangbin Ding
- Xin Li (ORCID: https://orcid.org/0000-0002-1237-4742)
- Yue Li (ORCID: https://orcid.org/0000-0001-9562-3136)
- Wenwen Zhang (ORCID: https://orcid.org/0000-0003-1285-3118)
- Linlin Zhang (ORCID: https://orcid.org/0000-0002-2819-9803)
- Tingting Ma (ORCID: https://orcid.org/0000-0002-8488-651X)
- Yiwen Guo (ORCID: https://orcid.org/0000-0003-1411-4693)
Institutions
- Tianjin Agricultural University (CN)
- Tianjin University (CN)
Publication Details
- Journal
- Animal Bioscience
- Published
- 2025-12-18
- DOI
- https://doi.org/10.5713/ab.250773
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00