Regional variations in cardiovascular risk predictions: a comparative analysis of Framingham, SCORE2, and WHO models across 53 countries
The CVD risk estimates produced by the WHO, SCORE2, and Framingham models varied significantly across regions, with poor consistency in identifying at-risk individuals in some regions. These discrepancies may lead to undertreatment and inefficient use of otherwise limited healthcare resources. Region-specific adaptations are needed to enhance risk targeting, promote equity, and improve the overall effectiveness of primary prevention.
Authors
- Yetong Liu
- Sidong Li (ORCID: https://orcid.org/0000-0002-4798-8920)
- Chao Li (ORCID: https://orcid.org/0000-0002-2552-413X)
- Yizhen Lyu (ORCID: https://orcid.org/0000-0002-8376-0747)
- Jiaheng Zhang (ORCID: https://orcid.org/0000-0002-2377-9796)
- Zhe Lv
- Wenming Bian (ORCID: https://orcid.org/0000-0002-9758-2179)
- Kangyu Chen (ORCID: https://orcid.org/0000-0002-7095-6767)
- Tao Chen (ORCID: https://orcid.org/0000-0002-5489-6450)
- Hui Yang (ORCID: https://orcid.org/0000-0001-9461-6727)
Institutions
- University of Science and Technology of China (CN)
- Liverpool School of Tropical Medicine (GB)
- Xi’an Children’s Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Global Health
- Published
- 2025-12-18
- DOI
- https://doi.org/10.7189/jogh.15.04323
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- UC Berkeley College of Chemistry