Comprehensive Analysis of the Value of Dynamic Changes in Circulating Tumor DNA in Small Cell Lung Cancer
Median ctDNA VAF<sub>max</sub> was strongly associated with OS, PFS, DFS, and ORR. Importantly, patients with detectable residual alterations at completion of prescribed chemotherapy exhibited a markedly shorter DFS, less than that of patients with lower detectable residual alterations, highlighting the potential utility of ctDNA in risk stratification and the value of early trial enrollment for high-risk subgroups.
Authors
- Ali Z. Rezvani (ORCID: https://orcid.org/0009-0006-0786-1294)
- Reza Ferdousi (ORCID: https://orcid.org/0000-0001-5511-5452)
- Abhishek Ajay (ORCID: https://orcid.org/0009-0001-8258-8447)
- Afshin Dowlati (ORCID: https://orcid.org/0000-0003-4535-6839)
- Minh Quang Lam (ORCID: https://orcid.org/0000-0003-1373-4241)
- Gary Wildey (ORCID: https://orcid.org/0000-0001-7105-1313)
- Pingfu Fu (ORCID: https://orcid.org/0000-0002-2334-5218)
- Seren Durer (ORCID: https://orcid.org/0009-0008-5105-4689)
- Peronne Joseph
- Zhengyi Chen (ORCID: https://orcid.org/0000-0002-2745-4454)
Institutions
- University Hospitals of Cleveland (US)
- University Hospitals Seidman Cancer Center (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1200/po-25-00574
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00