Natural History of Preterm Pre-labour Rupture of Membranes in a Singleton Primipara in a Rural Low-Resource Setting in the Absence of Early Antibiotic Intervention: a Case Report.

This case report presents the clinical course of a 33-year-old primiparous woman whom at 30 weeks of gestation experienced preterm pre-labour rupture of membranes (PPROM) in a low-resource setting. The patient, with a history of primary infertility, was managed conservatively without antibiotics for 28 days at a resource-limited health facility, where she was treated until clinical symptoms indicating chorioamnionitis appeared, leading to her referral. She underwent an emergency caesarean section at 34 weeks gestational age due to suspected chorioamnionitis resulting in the delivery of a healthy male infant. However, the baby developed neonatal jaundice which was successfully managed with phototherapy over five days. This case provides insight into the natural course of PPROM that lasted for 28 days, a condition that would have been ethically challenging to study in a research setting. It emphasizes the difficulties of managing PPROM in low-resource environments, especially when there is no immediate access to antibiotics and advanced neonatal care.

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PubMed
Published
2025-01-01
Primary Topic
Preterm Birth and Chorioamnionitis
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article
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article

Natural History of Preterm Pre-labour Rupture of Membranes in a Singleton Primipara in a Rural Low-Resource Setting in the Absence of Early Antibiotic Intervention: a Case Report.

Joseph Ifeanyichukwu Ikechebelu, Michel Chiedu Egbuniwe, W. A. Mube, Emeka Philip Igbodike et al.
PubMed
Preterm Birth and Chorioamnionitis
article

Natural History of Preterm Pre-labour Rupture of Membranes in a Singleton Primipara in a Rural Low-Resource Setting in the Absence of Early Antibiotic Intervention: a Case Report.

Joseph Ifeanyichukwu Ikechebelu, Michel Chiedu Egbuniwe, W. A. Mube, Emeka Philip Igbodike, Onyeka Chukwudalu Ekwebene, Emeka Okechukwu, Johnbosco E. Mamah, Nnanyelugo Chima Ezeora, Eziamaka Pauline Ezenkwele, Gerald Tochukwu Igwemadu, Ihechinyerem Kelechi Osuagwu, Ngozichukwu Gertrude Uzoewulu, Stanley Chigaemezu Egbogu, Ahizechukwu Chigoziem Eke, Odigonma Zinobia Ikpeze, Kesito Chikwendu Nwachukwu, Chigozie Geoffrey Okafor, George Uchenna Eleje, Emmanuel Chukwubuikem Egwuatu, Ekeuda Uchenna Nwankwo, Samuel Owusu-Sekyere, Onyecherelam Monday Ogelle, Gerald Okanandu Udigwe, Kingsley Chidiebere Nwaogu, Isaiah Chukwuebuka Umeoranefo, Agabus Iheanacho Nwachukwu, Chekwube Martin Obianyo, Chidinma Theresa Ezidiegwu, Blessing Ifunanya Enyi, Uchenna Clara Chijioke Ofoma, Augusta Amarachi Ibemere, Chinaza Michael Egbobe, Jessica Chinonso Onyeadurunu, Oluchukwu Praise Chukwudi, Esther Enekole Edoh
article en

Abstract

This case report presents the clinical course of a 33-year-old primiparous woman whom at 30 weeks of gestation experienced preterm pre-labour rupture of membranes (PPROM) in a low-resource setting. The patient, with a history of primary infertility, was managed conservatively without antibiotics for 28 days at a resource-limited health facility, where she was treated until clinical symptoms indicating chorioamnionitis appeared, leading to her referral. She underwent an emergency caesarean section at 34 weeks gestational age due to suspected chorioamnionitis resulting in the delivery of a healthy male infant. However, the baby developed neonatal jaundice which was successfully managed with phototherapy over five days. This case provides insight into the natural course of PPROM that lasted for 28 days, a condition that would have been ethically challenging to study in a research setting. It emphasizes the difficulties of managing PPROM in low-resource environments, especially when there is no immediate access to antibiotics and advanced neonatal care.

PubMedVol. 2(3)
East Tennessee State University (US), University of Port Harcourt Teaching Hospital (NG), Georgia Southern University (US), Nnamdi Azikiwe University Teaching Hospital (NG), Federal Teaching Hospital Abakaliki (NG), University of Nigeria Teaching Hospital (NG)
Openalex Percentile: Top 47%
Preterm Birth and Chorioamnionitis
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