Epithelial–Mesenchymal Transition and Stress Adaptations Underlie Yttrium-90 Resistance in Liver Cancer Cell Lines
TARE with 90Y is widely used for liver cancer, yet its molecular determinants of response are poorly understood. Using a diverse panel of liver cancer cell lines, we identify EMT, adhesion, and stress response pathways associated with resistance. These findings highlight candidate biomarkers and molecular vulnerabilities that may guide future therapeutic strategies and patient selection.
Authors
- Benjamin S. Strnad (ORCID: https://orcid.org/0000-0003-2308-1299)
- Jason D. Weber (ORCID: https://orcid.org/0000-0002-1069-6983)
- A. P. Zheleznyak (ORCID: https://orcid.org/0000-0002-1054-3768)
- J.C. Camacho (ORCID: https://orcid.org/0009-0006-9489-7382)
- Christine Yoon (ORCID: https://orcid.org/0000-0001-8434-3868)
- Nicholas O. Davidson (ORCID: https://orcid.org/0000-0003-3166-2229)
- Jingxia Liu (ORCID: https://orcid.org/0000-0002-9434-7907)
- Matthew A. Ciorba (ORCID: https://orcid.org/0000-0002-7656-0982)
- Valérie Blanc (ORCID: https://orcid.org/0009-0002-5701-5513)
- Prasanth Thunuguntla (ORCID: https://orcid.org/0009-0000-6652-5254)
- Jessica Silva-Fisher (ORCID: https://orcid.org/0000-0002-8146-9331)
- Daniel L.J. Thorek (ORCID: https://orcid.org/0000-0003-2437-1239)
- Ryan C. Fields (ORCID: https://orcid.org/0000-0001-6176-8943)
- Dhanusha Duraiyan (ORCID: https://orcid.org/0009-0009-2664-1977)
- C. Malone (ORCID: https://orcid.org/0000-0003-4111-9123)
- Shuang Wu (ORCID: https://orcid.org/0009-0003-3287-2380)
Institutions
- Albert Einstein College of Medicine (US)
- Washington University in St. Louis (US)
- Mallinckrodt (United States) (US)
- Washington University Medical Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0627
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Boston Scientific Corporation
- Alvin J. Siteman Cancer Center
- Eisai
- Sirtex Medical
- National Institutes of Health
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Research Resources