Cotrimoxazole in the intensive care unit: an impossible task for the fixed association in real life?
These findings underscore the need for individualized dosing in ICU patients, especially in patients with renal impairment or RRT. Current fixed-dose combination may not adequately reflect cotrimoxazole's complex pharmacokinetics in critical illness, stressing the importance of tailored strategies.
Authors
- Sophie Périnel (ORCID: https://orcid.org/0000-0001-8815-1580)
- Guillaume Thiéry (ORCID: https://orcid.org/0000-0002-8786-9061)
- Maria Filomena De Pina
- Manon Launay (ORCID: https://orcid.org/0000-0003-3113-7301)
- Romain Guilhaumou (ORCID: https://orcid.org/0000-0002-8344-412X)
- Franklin Bruna
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Institut de Neurosciences des Systèmes (FR)
- Health Services and Performance Research Laboratory (FR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Université Jean Monnet (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1093/jac/dkaf443
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00