Correlation between Uncoupling Protein3 (UCP3) Gene Polymorphism and Growth Traits of Hybrid Simmental

The uncoupling protein3 (UCP3) influences energy balance, basic metabolism and lipid metabolism.To study the relationship between uncoupling protein3 (UCP3) gene and growth traits in hybrid cattle (SimmentalNative Yellow Cattle), five novel SNPs (g.5465 GA, g.7921 CG, g.7953 AG, g.8018 TC, g.8162 TC) were identified by PCR-SSCP and sequencing.Result showed that g.5465GA, g.8162TC had moderate genetic diversity (0.250<PIC<0.500).Correlative analysis of five SNPs and body traits showed that SNP1 and SNP5 were associated with body weight, body length, body height, chest circumference (P < 0.05 or P<0.01) in hybrid cattle aged birth month, weaning months, six, twelve and eighteen months.The polymorphism, generated by T8162C mutation had the highest body height, body length of the hybrid cattle aged from birth month to eighteen months (P<0.01).Combination genotypes GACC had better performance than GGCC.Results showed that the polymorphism in bovine UCP3 might be one of the significant genetic factors that affect body performance, meanwhile, which supplies a good foundation and useful information for further study on UCP3 gene and cattle breeding.