Clinicopathological Correlation of Immunohistochemical Markers, Serum Biomarkers, and Masticatory Muscle Activity With the Severity of Oral Submucous Fibrosis
p63, Ki-67, SOX2, and E-cadherin demonstrate significant expression across normal mucosa, OSMF, and OSCC, supporting their role as markers of malignant transformation. However, these biomarkers do not reliably reflect disease severity within OSMF. Ultrasonographic and electromyography (EMG) assessments correlate with clinical progression and may serve as valuable adjuncts for early detection of muscle dysfunction in OSMF.
Authors
- Garima Goel (ORCID: https://orcid.org/0000-0001-9785-8115)
- Aman Kumar (ORCID: https://orcid.org/0000-0003-3599-057X)
- Vikas Gupta
- Shaila Sidam (ORCID: https://orcid.org/0000-0001-9946-8292)
- Utkal P Mishra
- Anjan Kumar Sahoo (ORCID: https://orcid.org/0000-0002-8073-6549)
- Ruchi Singh (ORCID: https://orcid.org/0000-0001-8094-4703)
- Ganakalyan Behera
- M M Ajeena
Institutions
- Patna Medical College and Hospital (IN)
- Indira Gandhi Institute of Medical Sciences (IN)
- All India Institute of Medical Sciences Bhopal (IN)
Publication Details
- Journal
- Cureus
- Published
- 2025-12-19
- DOI
- https://doi.org/10.7759/cureus.99679
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00