Modeling pathogenesis and progression of metabolic dysfunction-associated steatotic liver disease and therapeutic drug screening using hESC-derived mature polarized hepatocyte organoids
In summary, we established a novel in vitro MASLD model using hESC-derived P-hep-orgs. This model faithfully recapitulates key aspects of MASLD progression and serves as a valuable platform for investigating disease mechanisms and screening potential therapeutic compounds.
Authors
- Xiangting Cao (ORCID: https://orcid.org/0000-0001-8828-7509)
- Wenqing Yan (ORCID: https://orcid.org/0000-0002-5405-4026)
- Haibin Wu (ORCID: https://orcid.org/0000-0001-8628-4232)
- Jinghe Xie
- Shoupei Liu
- Yongjian Zhou (ORCID: https://orcid.org/0000-0003-1721-7639)
- Yuyou Duan (ORCID: https://orcid.org/0000-0002-1402-7402)
- Sen Chen (ORCID: https://orcid.org/0000-0002-5872-2597)
- Changlu Qin
- Xinyi Shi (ORCID: https://orcid.org/0009-0005-3807-3322)
- Peilin Liao
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Zhaoqing University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Cell Technology (China) (HK)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1186/s13287-025-04865-7
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- South China University of Technology
- Guangzhou First People's Hospital
- National Key Research and Development Program of China