Therapeutic effects of Total flavonoids of Epimedium Folium on sarcopenia via modulation of gut microbiota and bile acid metabolism
In the present study, TFE was shown to improve dexamethasone-induced muscle atrophy and degeneration in C2C12 myotubes, as evidenced by the restored expression of myogenic markers and the downregulation of atrophy-related genes and proteins. Additionally, TFE can attenuate sarcopenia progression in SAMP8 mice. Its effect was related to the regulation of the gut microbiota-bile acids-skeletal muscle axis.
Authors
- Yongli Chai
- Zhe Pan (ORCID: https://orcid.org/0000-0003-3079-959X)
- Zhao Ye (ORCID: https://orcid.org/0000-0001-9401-3993)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0001-5492-5509)
- Yujie Zhang (ORCID: https://orcid.org/0000-0002-9109-3171)
- Wei Liu (ORCID: https://orcid.org/0000-0002-9302-8170)
- Weian Yuan
- Jiewen Shi
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.exger.2025.113001
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00