Qiliqiangxin capsule improves the cognitive disorders in heart failure rats through regulating blood brain barrier function
QLQX improves cardiac function and mitigates cognitive decline in rats with heart failure. These protective effects likely involve the reduction of Ang II, AT1R, and ROS levels, alongside inhibition of the NF-κB pathway. Furthermore, QLQX upregulates the tight junction proteins Claudin-5 and Occludin, which helps preserve blood-brain barrier (BBB) integrity. This cascade of events ultimately reduces cerebral Aβ deposition.
Authors
- Haiyan Zhu (ORCID: https://orcid.org/0000-0002-1030-4601)
- Shuai Zhang (ORCID: https://orcid.org/0000-0002-5350-4048)
- Zhimiao Wang (ORCID: https://orcid.org/0000-0003-0189-466X)
- Jiaran Peng
- Yue Zhao (ORCID: https://orcid.org/0000-0003-2869-5257)
- Hongbing Zhao
- Yuqian Gao (ORCID: https://orcid.org/0000-0002-2956-2096)
- Jinfang Dou
- Murong Hei
Institutions
- Qingdao University (CN)
- Henan University of Traditional Chinese Medicine (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Zhengzhou City Hospital (CN)
- Qingdao Municipal Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.exger.2025.113007
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00