The association of serum vitamin D3 and vitamin D binding protein levels before and after treatment with the response to neoadjuvant chemotherapy in Egyptian breast cancer patients: a prospective observational study
Serum levels of vitamin D3 and VDBP significantly increased after NACT and were associated with favorable clinicopathological features and pCR. Only triple-negative subtype and baseline vitamin D were significantly predictive for pCR by multivariable analysis. These findings suggest that vitamin D3 and VDBP may serve as potential prognostic indicators in breast cancer management.
Authors
- Laila A. Eissa (ORCID: https://orcid.org/0000-0003-4470-0263)
- Amal Halim (ORCID: https://orcid.org/0000-0002-3061-1561)
- Ahmed Hassan (ORCID: https://orcid.org/0000-0002-5038-9590)
- Dina Y. El-Shabrawy
Institutions
- Mansoura University (EG)
Publication Details
- Journal
- Naunyn-Schmiedeberg s Archives of Pharmacology
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1007/s00210-025-04644-4
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund
- Mansoura University