Sex Specific Threshold Effects of Prenatal Stress on Striatal Microglia and Relevant Behaviors in Mice
High and immune stress affected adult striatal-dependent behavior, exceeding the threshold necessary for persistent impacts mostly in males, but all stress models affected embryonic microglia, suggesting a lower threshold for early neuroimmune impacts. Distinct severities and aspects of prenatal stress may therefore underlie different NDD-relevant outcomes.
Authors
- Venezia C. Roshko (ORCID: https://orcid.org/0009-0009-6770-3898)
- Sara V. Maurer (ORCID: https://orcid.org/0000-0001-5945-5278)
- Samantha L. Anema (ORCID: https://orcid.org/0009-0002-2496-2784)
- Hanna Elizabeth Stevens (ORCID: https://orcid.org/0000-0002-3906-0786)
- Sreelekha Kundu
- Maya M. Evans (ORCID: https://orcid.org/0000-0003-3534-0817)
- Jessica L. Dennis
- Rhett M. Ellerbroek
- Mia Dukle (ORCID: https://orcid.org/0009-0000-6502-8918)
Institutions
- University of Iowa (US)
Publication Details
- Journal
- Archives of Medical Research
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.arcmed.2025.103364
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00