Perinatal and adult western diet exposure alters hippocampal inflammatory and synaptic plasticity-related gene expression in rats
Acute exposure to a western diet in adulthood alters pre-translational pathways (<i>Il-6, Tnf-α, Bdnf-Trkb-Creb-1</i>) in the hippocampus of rats previously subjected to early-life western diet, indicating that perinatal programming and later dietary challenges interact to modulate hippocampal plasticity in a time- and diet stimulus-dependent manner.
Authors
- Taynara Rayane Lins da Silva (ORCID: https://orcid.org/0000-0002-2396-5847)
- Mireia Carla Miguel da Conceição
- Juliana da Silva Ribeiro
- Jairza Maria Barreto Medeiros (ORCID: https://orcid.org/0000-0003-3533-7108)
- Mírian Celly Medeiros Miranda David (ORCID: https://orcid.org/0000-0002-7152-8852)
- Rhowena Jane Barbosa de Matos (ORCID: https://orcid.org/0000-0001-5914-7304)
- Tradução Luíza Raimundo da Silva (ORCID: https://orcid.org/0000-0003-3077-7278)
- Elizabeth do Nascimento (ORCID: https://orcid.org/0000-0002-3618-2673)
- Oscar Lima
Institutions
- Universidade Federal da Bahia (BR)
- Universidade Federal do Recôncavo da Bahia (BR)
- Valve (United States) (US)
- Universidade Federal de Pernambuco (BR)
- Osmania University (IN)
Publication Details
- Journal
- Nutritional Neuroscience
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1080/1028415x.2025.2600516
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00