Acute myeloid leukemia presenting with gingival enlargement masked by a normal complete blood count: A case of delayed diagnosis and literature review

This case underscores the notion that gingival enlargement can serve as an initial indicator of AML, even in the absence of conventional hematological abnormalities. Dentists are required to exercise a high level of suspicion regarding systemic etiologies when confronted with severe, refractory, or rapidly progressive gingival enlargement that is disproportionate to local irritants. It is imperative that patients consult with hematologists at the earliest opportunity, and that repeated hematological evaluations are carried out in order to prevent misdiagnosis and delays in life-saving treatment.

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Publication Details

Journal
Medicine
Published
2025-12-19
DOI
https://doi.org/10.1097/md.0000000000046684
Primary Topic
Oral and gingival health research
Type
article
Field-Weighted Citation Impact
0.00
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article

Acute myeloid leukemia presenting with gingival enlargement masked by a normal complete blood count: A case of delayed diagnosis and literature review

W. D. Li, Fu-peng Ding, Dandan Wu, Liangping Luo
Medicine
Oral and gingival health research
article

Acute myeloid leukemia presenting with gingival enlargement masked by a normal complete blood count: A case of delayed diagnosis and literature review

W. D. Li, Fu-peng Ding, Dandan Wu, Liangping Luo
article en

Abstract

This case underscores the notion that gingival enlargement can serve as an initial indicator of AML, even in the absence of conventional hematological abnormalities. Dentists are required to exercise a high level of suspicion regarding systemic etiologies when confronted with severe, refractory, or rapidly progressive gingival enlargement that is disproportionate to local irritants. It is imperative that patients consult with hematologists at the earliest opportunity, and that repeated hematological evaluations are carried out in order to prevent misdiagnosis and delays in life-saving treatment.

MedicineVol. 104(51)
Guiyang Medical University (CN), Affiliated Hospital of Guizhou Medical University (CN)
Openalex Percentile: Top 42%
Oral and gingival health research
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