A nomogram to predict large-for-gestational-age in term newborns: A retrospective single-center study

This study aims to build and validate a nomogram for large-for-gestational-age (LGA) prediction in full-term (37-41 weeks of gestation) newborns. This retrospective single-center study included consecutive full-term deliveries (37-41 weeks' gestation) at Yuyao People's Hospital of Zhejiang Province from January to December 2021. Participants were randomly assigned (7:3) to training and validation sets. The current study included 1481 deliveries (training n = 1017; validation n = 464). Gestational age (odds ratio [OR] = 1.32, 95% confidence interval [CI]: 1.13-1.54), gestational weight gain (OR = 1.07, 95% CI: 1.03-1.12), symphysis-fundal height (OR = 1.14, 95% CI: 1.03-1.27), fetal abdominal circumference (OR = 1.10, 95% CI: 1.09-1.12), triglycerides (OR = 1.49, 95% CI: 1.08-2.05), gestational diabetes mellitus (OR = 2.05, 95% CI: 1.33-3.14), and pre-pregnancy body mass index < 18.5 (OR = 0.48, 95% CI: 0.28-0.81) had independent associations with LGA. A nomogram was developed, and receiver operating characteristic curves had areas under the curves of 0.846 (95% CI: 0.821-0.871) and 0.802 (95% CI: 0.761-0.842) in the training and validation sets, respectively. Seven factors were independently associated with LGA. A nomogram was developed and showed favorable predictive performance.