Metabolically hijacked Listeria monocytogenes synergizes STING activation and dual cell death for enhanced antitumor immunotherapy
These findings establish metabolic hijacking of bacterial vectors as a paradigm-shifting strategy that integrates direct tumor killing with multimodal immune activation, overcoming key barriers in microbial immunotherapy.
Authors
- Haigang Zhang (ORCID: https://orcid.org/0000-0002-2066-9196)
- Meiping Huang (ORCID: https://orcid.org/0000-0002-0745-852X)
- Wenjun Shan (ORCID: https://orcid.org/0000-0001-5983-8455)
- Tao Liu (ORCID: https://orcid.org/0000-0001-9529-6550)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-0018-3903)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Ya Liu (ORCID: https://orcid.org/0000-0002-7816-684X)
- Qunfang Yang
- Jianhua Huang
- Cheng Zhong (ORCID: https://orcid.org/0000-0003-2691-0515)
- Lanfang Zhang (ORCID: https://orcid.org/0000-0002-7790-0061)
- Zhihao Zhao (ORCID: https://orcid.org/0009-0004-8973-8622)
Institutions
- Army Medical University (CN)
- Dalian Medical University (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1186/s12951-025-03945-3
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00