Galectin-3 in endometrial small extracellular vesicles promotes cytotrophoblast cell fusion during the implantation phase
Our findings demonstrate that endometrial sEVs enriched in galectin-3 during the implantation phase promote CT differentiation into ST, underscoring a novel role for sEV-mediated protein delivery in regulating early placental development and suggesting potential diagnostic and therapeutic applications in reproductive medicine.
Authors
- Baku Nakakita (ORCID: https://orcid.org/0009-0007-6762-5696)
- Yusuke Sagae
- Asuka Okunomiya (ORCID: https://orcid.org/0009-0003-4982-5775)
- Shimpei Shitanaka
- Masaki Mandai (ORCID: https://orcid.org/0000-0003-4428-8029)
- Akihiro Yanai
- Yoshimi Kitawaki
- Akihito Horie
- Mitsuhiro Nakamura (ORCID: https://orcid.org/0000-0002-6406-2097)
- A. Ikeda (ORCID: https://orcid.org/0000-0003-0044-9142)
- Shinji Ito
- S Imakita
- Tsutomu Ohara
Institutions
- Baylor College of Medicine (US)
- Kyoto University (JP)
- Kyoto Medical Center (JP)
- Mitsubishi Kyoto Hospital (JP)
- Kyoto University Hospital (JP)
- Kitano Hospital (JP)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1186/s12964-025-02586-1
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Kanazawa University
- Japan Society for the Promotion of Science