Aldolase a coordinates macropinocytic nutrient scavenging and lysosomal degradation in lung cancer by interacting with V-ATPase
Our study identifies a novel, non-enzymatic function of ALDOA as a critical regulator of lysosomal degradation of macropinocytosed proteins via interaction with V-ATPase. This mechanism is essential for metabolic adaptation and growth of KRAS-mutant tumors under stress conditions. Targeting ALDOA offers a promising therapeutic strategy for cancers that rely on extracellular nutrient scavenging.
Authors
- Jun‐Kyu Byun (ORCID: https://orcid.org/0000-0002-2191-5520)
- Seunghyeong Lee
- Jonghwa Jin (ORCID: https://orcid.org/0000-0002-9286-3190)
- Keun‐Gyu Park (ORCID: https://orcid.org/0000-0002-8403-1298)
- Jaebon Lee (ORCID: https://orcid.org/0000-0001-5600-6354)
- Jae Won Yun (ORCID: https://orcid.org/0000-0002-9029-8036)
- Daehoon Kim (ORCID: https://orcid.org/0000-0002-9736-450X)
- Seokmin Jeong
- Yeon‐Kyung Choi (ORCID: https://orcid.org/0000-0003-0996-6437)
Institutions
- Kyungpook National University Hospital (KR)
- Kyungpook National University (KR)
- Veterans Health Service Medical Center (KR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1186/s12964-025-02591-4
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00