Prolonged Skin Graft Survival and Histocompatibility in Highly Inbred Miniature Swine
At COI of 92%, highly inbred swine experienced prolonged STSG survival, but persistent minor histocompatibility antigen disparities caused delayed skin graft rejection. Most pigs with COI of 94% accepted reciprocal skin grafts long-term without immunosuppression, indicating homozygosity of the skin graft donors for all relevant histocompatibility loci. Organ transplants within this new inbred line are expected to be accepted indefinitely without a requirement for exogenous immunosuppression, facilitating experiments requiring genetically identical cells from different animals.
Authors
- Elin Manell (ORCID: https://orcid.org/0000-0002-4491-7609)
- Satyajit Patwardhan (ORCID: https://orcid.org/0000-0002-6334-0788)
- Ibrahim Batal (ORCID: https://orcid.org/0000-0002-0686-5457)
- Julie Hong (ORCID: https://orcid.org/0000-0002-2035-0660)
- H.A. Mulder (ORCID: https://orcid.org/0000-0003-2124-4787)
- Joshua Weiner (ORCID: https://orcid.org/0000-0003-3780-1875)
- Ishit Chauhan
- M. Esad Gunes (ORCID: https://orcid.org/0000-0002-7025-3826)
- J. Scott Arn
- David H. Sachs
Institutions
- NewYork–Presbyterian Hospital (US)
- Columbia University Irving Medical Center (US)
- Swedish University of Agricultural Sciences (SE)
- Presbyterian Hospital (US)
- Columbia University (US)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1097/txd.0000000000001895
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 0.00