Impaired hepatic metabolism in Hereditary Fructose Intolerance confers fructose-independent risk for steatosis and hypertriglyceridemia
Aldob deletion caused fructose-independent hyperlipidemia and steatosis upon fasting in rats. Individuals with HFI may have risk for hepatic disease and hyperlipidemia even upon fructose abstinence suggesting additional therapies may be needed to mitigate disease.
Authors
- Elaine Kuang
- Natalie A. Daurio
- Melissa A. Fulham
- Craig Hyde (ORCID: https://orcid.org/0000-0002-6939-287X)
- Scott P. Kelly (ORCID: https://orcid.org/0000-0002-5421-873X)
- Melissa Miller (ORCID: https://orcid.org/0000-0002-8570-3981)
- Gang Xing (ORCID: https://orcid.org/0000-0001-8857-9421)
- Gregory J. Tesz (ORCID: https://orcid.org/0000-0003-4658-5908)
- Kendra K. Bence (ORCID: https://orcid.org/0000-0002-5879-4726)
- Evanthia Pashos
- Michelle Clasquin
- Magalie Boucher (ORCID: https://orcid.org/0009-0008-6293-6775)
- Ramya Gamini
- Ying Zhang (ORCID: https://orcid.org/0000-0002-5812-372X)
- Zhongyuan Sun
- Sylvie Perez
- John D Griffin
- Rachel Poskanzer
- Josh Fienman
Institutions
- Pfizer (United States) (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.molmet.2025.102310
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00