Cortisol-to-DHEAS awakening response ratio in people with dementia and family caregivers: Associations with age, dementia severity and agitation
Although average ratio did not differ between PWD and caregivers, it increased more steeply with age at higher dementia severity and agitation. These findings highlight the cortisol-to-DHEA(S) awakening response ratio as a non-invasive and clinically relevant biomarker reflecting symptom-linked neuroendocrine heterogeneity in dementia.
Authors
- Gabriella Engström (ORCID: https://orcid.org/0000-0002-2729-995X)
- Wanrui Wei (ORCID: https://orcid.org/0000-0003-2840-2100)
- Töres Theorell (ORCID: https://orcid.org/0000-0002-3845-3545)
- Azita Emami (ORCID: https://orcid.org/0000-0003-2608-9691)
Institutions
- Dalarna University (SE)
- Stockholm University (SE)
- Karolinska Institutet (SE)
- Yale University (US)
Publication Details
- Journal
- Comprehensive Psychoneuroendocrinology
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.cpnec.2025.100334
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00