Distinct medial temporal volumetric signatures in extra‐medial temporal lobe lesional epilepsy
This study looked at changes in two brain structures, the amygdala and hippocampus, in people with treatment-resistant epilepsy associated with lesions outside the medial temporal lobe. We found that patients with lesions on the left side often had a small left hippocampus, while those with right-sided lesions showed more complex patterns, including enlargement of both the amygdala and left hippocampus and less frequent small right hippocampus. These findings suggest that detailed measurements of brain asymmetry can uncover changes missed by standard assessment and may help doctors better locate seizure activity and plan treatments.
Authors
- Sara K. Inati (ORCID: https://orcid.org/0000-0002-7587-5085)
- Alexandrea Kilgore‐Gomez
- Yonatan Serlin (ORCID: https://orcid.org/0000-0001-5216-120X)
- Tianxia Wu (ORCID: https://orcid.org/0000-0001-6888-658X)
- William H. Theodore (ORCID: https://orcid.org/0000-0002-4669-5747)
- Shareena Rahman (ORCID: https://orcid.org/0009-0001-3110-2734)
- Elena Hayday
- Bijal Patel (ORCID: https://orcid.org/0000-0002-8893-3483)
Institutions
- Children's Hospital of Philadelphia (US)
- University of Alabama at Birmingham Hospital (US)
- University of Nevada, Reno (US)
- University of Alabama at Birmingham (US)
- National Institute of Neurological Disorders and Stroke (US)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1002/epi4.70201
- Primary Topic
- Hemispheric Asymmetry in Neuroscience
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- NHLBI Division of Intramural Research