Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures
Isoflurane causes a failure of SERCA-dependent calcium removal by inhibition of mitochondrial production of ATP. The increase in intracellular calcium leads to early signs of cellular toxicity.
Authors
- Margaret M. Sedensky (ORCID: https://orcid.org/0000-0001-9822-6558)
- Philip G. Morgan (ORCID: https://orcid.org/0000-0003-4857-2756)
- Jan‐Marino Ramirez (ORCID: https://orcid.org/0000-0002-5626-3999)
- Sangwook Jung
Institutions
- University of Washington (US)
- Norcliffe Foundation (US)
- Seattle Foundation (US)
- Allen Institute (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1097/aln.0000000000005910
- Citations
- 1
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.32