Long-term Real-world Survival Outcomes with Dual Immune Checkpoint Blockade in Synchronous Metastatic Renal Cell Carcinoma: Implications for the Design of Prospective Cytoreductive Nephrectomy Trials
We looked at outcomes for patients with metastatic kidney cancer who were treated with immunotherapy while their kidney tumour was still in place. Patients who responded well to immunotherapy were likely to survive for a long time, whether or not they then had surgery to remove their kidney tumour. Our results will help in the design of analyses for clinical trials that are already testing the role of delayed surgery for metastatic kidney tumours.
Authors
- Laura Marandino (ORCID: https://orcid.org/0000-0001-7120-2505)
- L. Jurascheck
- John B.A.G. Haanen (ORCID: https://orcid.org/0000-0001-5884-7704)
- Ekaterini Boleti
- Luna van den Brink (ORCID: https://orcid.org/0000-0001-5716-8574)
- Sofie Wilgenhof (ORCID: https://orcid.org/0000-0002-3309-4555)
- Samra Turajlic (ORCID: https://orcid.org/0000-0001-8846-136X)
- Niels M. Graafland
- Johannes C. van der Mijn (ORCID: https://orcid.org/0000-0001-5051-5860)
- Axel Bex (ORCID: https://orcid.org/0000-0002-8499-2662)
- Elisabeth E. Fransen van de Putte
- Johannes V. van Thienen (ORCID: https://orcid.org/0009-0004-6795-0497)
- Zayd Tippu (ORCID: https://orcid.org/0000-0002-3602-0770)
- Patricia Zondervan (ORCID: https://orcid.org/0000-0003-0812-078X)
- Thomas Powles
Institutions
- Royal Marsden NHS Foundation Trust (GB)
- Queen Mary University of London (GB)
- Royal Free London NHS Foundation Trust (GB)
- Dutch Cancer Society (NL)
- The Francis Crick Institute (GB)
- The Netherlands Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.euros.2025.12.004
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00