Cortactin Suppresses mTOR-Dependent Senescence in Circulating Tumor Cells
The cytoskeleton regulator cortactin governs senescence induction and maintenance in melanoma circulating tumor cells, providing an axis that can be targeted by a sequential therapeutic strategy to block metastasis.
Authors
- Qingfeng Chen (ORCID: https://orcid.org/0000-0001-6437-1271)
- Binyu Zhang (ORCID: https://orcid.org/0009-0009-5033-992X)
- Xin Hong (ORCID: https://orcid.org/0000-0002-9671-0116)
- Haoyuan Tan (ORCID: https://orcid.org/0009-0002-8558-9717)
- Lühua Wang (ORCID: https://orcid.org/0000-0002-5272-1681)
- Hailiang Hu (ORCID: https://orcid.org/0000-0001-9205-1603)
- Xinghua Pan (ORCID: https://orcid.org/0000-0002-7421-8155)
- Weinan Guo (ORCID: https://orcid.org/0000-0002-3517-3898)
- Shuqian Zheng (ORCID: https://orcid.org/0009-0004-3643-895X)
- Jialing Liu (ORCID: https://orcid.org/0000-0002-8242-2455)
- Lingyun Dai (ORCID: https://orcid.org/0000-0001-9386-5967)
- Jianyang Hu (ORCID: https://orcid.org/0000-0003-4911-6816)
- Hao Yu (ORCID: https://orcid.org/0000-0003-2793-7912)
- Hongchang Li (ORCID: https://orcid.org/0000-0003-0072-4706)
- Fan Yang (ORCID: https://orcid.org/0000-0001-8913-3413)
- Xuefei Liu (ORCID: https://orcid.org/0000-0002-1843-6107)
- Mao Zhao (ORCID: https://orcid.org/0009-0002-8663-7266)
- Ke Liu (ORCID: https://orcid.org/0009-0000-9329-6450)
- H Zhou (ORCID: https://orcid.org/0009-0002-9152-4856)
- Jianglin Zhang (ORCID: https://orcid.org/0000-0002-6701-2044)
- Guanyin Huang (ORCID: https://orcid.org/0009-0004-6049-111X)
- Junhao Chen (ORCID: https://orcid.org/0009-0009-1282-2195)
Institutions
- Macau University of Science and Technology (MO)
- Agency for Science, Technology and Research (SG)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- National Cancer Center (US)
- ShenZhen People’s Hospital (CN)
- Academy of Mathematics and Systems Science (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Shenzhen Technology University (CN)
- Xijing Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Institute of Molecular and Cell Biology (SG)
- Air Force Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1175
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00