Durable Complete Response and Potential Cure With Systemic Chemotherapy in Metastatic Gastric Cancer: A Case Series of Patients

The introduction of molecular targeted agents and immunotherapy has expanded the chance of potential cure. The enrichment of dMMR, HER2-positive, and CPS-high tumors among potentially cured cases highlights the urgent need to develop effective therapies for those lacking actionable biomarkers.

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Publication Details

Journal
JCO Oncology Practice
Published
2025-12-19
DOI
https://doi.org/10.1200/op-25-00705
Primary Topic
Gastric Cancer Management and Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

Durable Complete Response and Potential Cure With Systemic Chemotherapy in Metastatic Gastric Cancer: A Case Series of Patients

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JCO Oncology Practice
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Durable Complete Response and Potential Cure With Systemic Chemotherapy in Metastatic Gastric Cancer: A Case Series of Patients

Takahiro Kinoshita, Takeo Fujita, Kohei Shitara, Ukyo Okazaki, Keigo Chida, Kyosuke Seguchi, Naoya Sakamoto, Yuki Matsubara, Takuya Ogura, Tadayoshi Hashimoto, Daisuke Kotani, Masahiro Yura, Hideaki Bando, Izuma Nakayama, Akinori Kobayashi, Yasutoshi Kuboki, Saori Mishima, Yu Miyashita, Takashi Kojima, Dai Okemoto, Mitsumasa Yoshida, Yoshimasa Shimizu, Takumi Habu, Kazumasa Yamamoto, Kazuma Sato, Shigeru Ushiyama
article en

Abstract

The introduction of molecular targeted agents and immunotherapy has expanded the chance of potential cure. The enrichment of dMMR, HER2-positive, and CPS-high tumors among potentially cured cases highlights the urgent need to develop effective therapies for those lacking actionable biomarkers.

JCO Oncology Practice
Mito Red Cross Hospital (JP), National Cancer Center Hospital East (JP)
Openalex Percentile: Top 40%
Gastric Cancer Management and Outcomes
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