Integrated local and global Ki67 profiling for prognostic stratification and therapeutic guidance in high-grade neuroendocrine neoplasms: a multicenter validation study
IL-GKi67 is an interpretable and validated digital biomarker that overcomes the limitations of manual Ki67 assessment. By integrating local and global proliferation patterns, it improves risk stratification and provides a practical tool to guide personalized adjuvant chemotherapy decisions for patients with HGNENs.
Authors
- Dan Huang (ORCID: https://orcid.org/0000-0002-7001-1325)
- Heli Gao (ORCID: https://orcid.org/0000-0001-6094-5776)
- Zhigang Zhu (ORCID: https://orcid.org/0000-0002-0911-179X)
- Xiahai Zhuang (ORCID: https://orcid.org/0000-0003-4351-4979)
- Qiongyan Zhang (ORCID: https://orcid.org/0000-0001-9093-3418)
- Weiqi Sheng
- Jie Chen (ORCID: https://orcid.org/0009-0002-1536-2007)
- Qing-Chao Chen (ORCID: https://orcid.org/0000-0002-1216-5609)
- Lijuan Cao (ORCID: https://orcid.org/0000-0002-1755-1541)
- Jin Chu (ORCID: https://orcid.org/0000-0003-4229-1304)
- Yun Liang (ORCID: https://orcid.org/0000-0003-3759-2997)
- Feng Tang (ORCID: https://orcid.org/0000-0003-0870-8890)
- Yuan Ji (ORCID: https://orcid.org/0000-0001-7835-6662)
- Yihui Ma
- Haiyu Gong
- Juanhong Shi
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Second Military Medical University (CN)
- Peking University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1097/js9.0000000000004574
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00