Necrotizing soft-tissue infections survival guide in adult patients: A position statement by the Global Alliance for Infections in Surgery
Necrotizing soft-tissue infections (NSTIs) are acute, rapidly progressive infections of soft tissues, often associated with signs of severe systemic toxicity and progressive multi-organ failure. This rapid, often fatal progression of local disease mandates timely diagnosis. Delays in diagnosis and treatment may have dire consequences. Effective treatment includes appropriate debridement associated with directed antibiotic therapy and hemodynamic support. Early surgical debridement with complete removal of necrotic tissue, including potential amputation, is essential to decrease mortality and other complications. The initial treatment of patients with NSTIs requires collaboration between surgeons, intensivists, and infectious disease specialists. Extensive tissue debridements may create challenges for wound care, preservation of function, reconstruction, and cosmesis, requiring ongoing multidisciplinary collaboration. This evidence-based position statement has been signed by a representative multidisciplinary working group of experts, with its main objective being to describe best practices for the first-line management of NSTIs in adult patients.
Authors
- Francesco M. Labricciosa
- Majdi N. Al‐Hasan (ORCID: https://orcid.org/0000-0001-6501-492X)
- Andreas Hecker (ORCID: https://orcid.org/0000-0002-7704-7494)
- Mauro Podda (ORCID: https://orcid.org/0000-0001-9941-0883)
- William G. Cheadle
- Ryan C. Maves (ORCID: https://orcid.org/0000-0001-6234-6160)
- Gabriele Vigutto
- Sanjay Marwah (ORCID: https://orcid.org/0000-0002-0300-2779)
- Ignacio Martín‐Loeches (ORCID: https://orcid.org/0000-0002-5834-4063)
- Federico Coccolini (ORCID: https://orcid.org/0000-0001-6364-4186)
- Jan Ulrych (ORCID: https://orcid.org/0000-0002-5225-9562)
- Massimo Sartelli (ORCID: https://orcid.org/0000-0003-3202-7542)
- Carlo Vallicelli (ORCID: https://orcid.org/0000-0002-9523-1324)
- Belinda De Simone (ORCID: https://orcid.org/0000-0002-7956-3097)
- Philippe Montravers (ORCID: https://orcid.org/0000-0002-3422-5705)
- Raul Sérgio Martins Coimbra (ORCID: https://orcid.org/0000-0002-3759-6851)
- Timothy Craig Hardcastle (ORCID: https://orcid.org/0000-0002-3967-0234)
- Marc Léone (ORCID: https://orcid.org/0000-0002-3097-758X)
- Luis Buonomo
- Richard Watkins (ORCID: https://orcid.org/0000-0003-1464-3376)
- Andrew W. Kirkpatrick (ORCID: https://orcid.org/0000-0002-1692-5919)
- Pierre Tattevin (ORCID: https://orcid.org/0000-0003-3617-5411)
- Cristian Tranà
- Therèse M. Duane
- Jeffrey Tessier
- Jordi Rello
- Fausto Catena
Institutions
- University of Macerata (IT)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1097/ta.0000000000004833
- Citations
- 3
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.64