Genetic and Electrophysiological Characterization of Acute Recurrent Pancreatitis in Israeli Patients
More than half of acute recurrent pancreatitis cases had a genetic basis, presenting at a younger age. CFTR variants were the most prevalent. The high prevalence of the PRSS1 p.Lys23Arg variant among Jewish Georgian individuals suggests a potential founder effect. These findings highlight the importance of genetic evaluation in the diagnosis and management of acute recurrent pancreatitis.
Authors
- Vinciane Rebours (ORCID: https://orcid.org/0000-0002-0000-4525)
- Michael Cohen (ORCID: https://orcid.org/0000-0001-8941-1575)
- Ron Shaoul (ORCID: https://orcid.org/0000-0001-5667-8759)
- Liron Birimberg‐Schwartz (ORCID: https://orcid.org/0000-0001-9014-3686)
- Efrat Broide (ORCID: https://orcid.org/0000-0003-0427-8491)
- Baruch Yerushalmi (ORCID: https://orcid.org/0000-0001-5178-865X)
- Michael Wilschanski (ORCID: https://orcid.org/0000-0002-6223-5185)
- Claude Férec (ORCID: https://orcid.org/0000-0002-2325-0710)
- Oren Ledder (ORCID: https://orcid.org/0000-0001-8109-814X)
- Ayelet Gamliel (ORCID: https://orcid.org/0000-0002-0100-6338)
- Chani Topf‐Olivestone
- Michal Kori (ORCID: https://orcid.org/0000-0002-5519-8259)
- Emmanuelle Masson (ORCID: https://orcid.org/0000-0001-9777-523X)
- Manar Matar (ORCID: https://orcid.org/0000-0002-5270-2691)
- Philippe Ruszniewski
- Jian‐Min Chen (ORCID: https://orcid.org/0000-0002-2424-3969)
- Maayan Tiosano
Institutions
- Ben-Gurion University of the Negev (IL)
- Inserm (FR)
- Université de Bretagne Occidentale (FR)
- Hebrew University of Jerusalem (IL)
- Université Paris Cité (FR)
- Hôpital Beaujon (FR)
- Hadassah Medical Center (IL)
- Assuta Medical Center (IL)
- Soroka Medical Center (IL)
- Rambam Health Care Campus (IL)
- Shaare Zedek Medical Center (IL)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Schneider Children's Medical Center (IL)
- Assaf Harofeh Medical Center (IL)
- Centre Hospitalier Régional Universitaire de Brest (FR)
- Edmond and Lily Safra Children's Hospital (IL)
- Génétique, Génomique Fonctionnelle et Biotechnologies (FR)
- Clalit Health Services (IL)
Publication Details
- Journal
- Pancreas
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1097/mpa.0000000000002617
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00