AR-R17779, an agonist of alpha-7 nicotinic acetylcholine receptor, attenuates trauma-induced lung epithelial glycocalyx injury by suppressing macrophage proinflammatory activity
AR-R17779 attenuated trauma-induced ALI by preventing lung epithelial glycocalyx breakdown, which may result from the suppression of macrophage proinflammatory activity. Future research should test AR-R17779 as an adjunct to resuscitation aimed at limiting dysregulated macrophage activation and ALI after trauma.
Authors
- Katie Pool
- Matthew A. Heard (ORCID: https://orcid.org/0000-0003-1131-9597)
- Wooil Choi (ORCID: https://orcid.org/0000-0001-7311-8171)
- Brian P. Eliceiri (ORCID: https://orcid.org/0000-0003-1811-1916)
- Todd W. Costantini (ORCID: https://orcid.org/0000-0002-0215-5327)
- Raul Sérgio Martins Coimbra (ORCID: https://orcid.org/0000-0002-3759-6851)
- Keita Nakatsutsumi (ORCID: https://orcid.org/0000-0001-6140-8761)
Institutions
- University of Minnesota Medical Center (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1097/ta.0000000000004829
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00