Lactate modulates TGF-β1– and IL-1β–induced transcriptional programs in human dermal fibroblasts: Potential implications for wound management
These findings suggest that, because of a potential biphasic response, high lactate treatment of NHDFs exhibits immunosuppressive effects, indicating that metabolic regulation may help mitigate tissue damage. Additionally, pharmacological manipulation of histone modifications or metabolic rebalancing may serve as intriguing therapeutic interventions.
Authors
- Gregory W. Thomas (ORCID: https://orcid.org/0000-0002-5708-8790)
- David Bar‐Or (ORCID: https://orcid.org/0000-0002-3685-314X)
- Kaysie L. Banton (ORCID: https://orcid.org/0000-0001-6514-3166)
- Carlos H. Palacio
- David Acuña
- Christopher Zaw-mon
Institutions
- Swedish Medical Center (US)
- B2 (Slovenia) (SI)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1097/ta.0000000000004836
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00