Oxidative Alkynylation of Alcohols or Aldehydes Using RuHCl(CO)(PPh <sub>3</sub> ) <sub>3</sub> : Ynones Made Easy
Structurally diverse alcohols (or aldehydes) react with (triisopropylsilyl)acetylene to form α,β-acetylenic ketones (ynones) in good to excellent yield. This method for oxidative alkynylation exploits the commercially available air-stable precatalyst RuHCl(CO)(PPh<sub>3</sub>)<sub>3</sub> rather than the iodide-bound precatalyst RuI(η<sup>3</sup>-C<sub>3</sub>H<sub>5</sub>)(CO)<sub>3</sub>, which is sensitive and not available for purchase.
Authors
- Weijia Shen (ORCID: https://orcid.org/0000-0001-6345-3371)
- Michael J. Krische (ORCID: https://orcid.org/0000-0001-8418-9709)
- Sebastian Höthker (ORCID: https://orcid.org/0009-0008-2058-4142)
- Colin E. Hayter
Institutions
- The University of Texas at Austin (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1021/acs.orglett.5c04840
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00