A Genetic Atlas of Rheumatoid Arthritis Integrating Immune Traits and Plasma Proteins Identifies Genetically Supported Candidate Effectors along the Coagulation-Inflammation Axis
Genetic evidence supports an immune→coagulation causal axis in RA, nominating thrombin/F2 as a translational node and motivating a dual therapeutic rationale: suppressing procoagulant inflammation while enhancing genetically protective pathways (e.g., CD39+ and sRAGE). These findings provide a genetically anchored prioritization framework and motivate subsequent experimental and trial-proximal validation.
Authors
- Cheng Zhu (ORCID: https://orcid.org/0000-0002-1718-565X)
- Ye Zhang (ORCID: https://orcid.org/0009-0008-7238-1013)
- Huiqiong Zeng (ORCID: https://orcid.org/0000-0002-2124-1837)
- Shuo Zhao (ORCID: https://orcid.org/0000-0002-1239-4647)
- Wei Liu (ORCID: https://orcid.org/0009-0006-8142-0489)
- Zhiquan Cai (ORCID: https://orcid.org/0000-0002-1988-1704)
- Gaofeng Xiong
- Junda Lai
Institutions
- Jinan University (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
- Guangdong Province Women and Children Hospital (CN)
- Beijing Sport University (CN)
Publication Details
- Journal
- International Archives of Allergy and Immunology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1159/000550107
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00