Immune Benefits of Psychosocial Intervention for Atopic Dermatitis in Hong Kong Children

Purpose: To evaluate the efficacy of an Integrative Body–Mind–Spirit (IBMS) group intervention in modulating inflammatory cytokine balance and improving clinical outcomes in children with atopic dermatitis. Methods: In a randomized, waitlist-controlled trial conducted in Hong Kong, 141 parent–child dyads were assigned to either the IBMS intervention ( n = 71) or a waitlist control ( n = 70). The IBMS intervention consisted of 6 weekly 3-hour group sessions. Outcomes included inflammatory cytokine levels, eczema severity, physical and emotional impact, and quality of life, assessed at baseline and post-intervention. Results: The IBMS group showed significant reductions in eczema severity and improvements in physical and emotional well-being and quality of life. Significant decreases in cytokine levels were also observed, indicating a shift toward immune balance. Discussion: The IBMS psychosocial intervention demonstrated immunological and clinical benefits, underscoring its potential as a non-pharmacological approach for pediatric eczema.