Predicting the influence of homologous recombination repair deficiency genes on glioma heterogeneity and patient prognosis using multi-omics analysis and machine learning
Our HRD Index model based on these seven genes significantly correlated with clinical prognosis in glioma patients and holds promise for guiding clinical management.
Authors
- Zhouqing Chen (ORCID: https://orcid.org/0000-0001-7517-7036)
- Zheng Zhan (ORCID: https://orcid.org/0000-0003-3029-4145)
- Jiaxuan Li (ORCID: https://orcid.org/0000-0002-3999-4183)
- Zhong Wang (ORCID: https://orcid.org/0000-0002-7342-0845)
- Xin Wu (ORCID: https://orcid.org/0009-0000-0980-1136)
- Long‐Yuan Li (ORCID: https://orcid.org/0000-0001-7472-8318)
- Mei Chang
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1371/journal.pone.0337731
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00