Tracking B cell immunity during perturbation of hepatitis B infection induced by treatment withdrawal
Differences in global and HBs-specific B cell immunity associate with HBsAg loss, whereas HBc-MBC temporally associates with flares, following withdrawal of prolonged NA treatment. Our results underscore the need to further explore the potential of B cell targets for monitoring and enhancing HBV functional cure in larger cohorts.
Authors
- Maëlle Locatelli (ORCID: https://orcid.org/0000-0002-0825-7180)
- Alice R. Burton (ORCID: https://orcid.org/0000-0003-1049-1176)
- Nikolai Novikov (ORCID: https://orcid.org/0000-0002-8405-6559)
- Sabela Lens (ORCID: https://orcid.org/0000-0003-4900-411X)
- Anna Jeffery-Smith (ORCID: https://orcid.org/0000-0003-2895-7608)
- Xavier Forns (ORCID: https://orcid.org/0000-0002-8188-1764)
- Simon P. Fletcher (ORCID: https://orcid.org/0000-0003-1987-6179)
- Sofía Pérez‐del‐Pulgar (ORCID: https://orcid.org/0000-0002-9890-300X)
- Anna Pocurull (ORCID: https://orcid.org/0000-0002-1970-1822)
- Mireia García‐López (ORCID: https://orcid.org/0000-0002-9643-7172)
- Mala K. Maini (ORCID: https://orcid.org/0000-0001-6384-1462)
- Jessica Davies
Institutions
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Gilead Sciences (United States) (US)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Institute of Infection and Immunity (CA)
- University College London (GB)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Gut
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1136/gutjnl-2024-333309
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Asociación Española para el Estudio del Hígado
- Wellcome Trust
- Centres de Recerca de Catalunya
- National Institute for Health and Care Research
- European Commission
- Generalitat de Catalunya
- British Infection Association
- University College London Hospitals NHS Foundation Trust
- Societat Catalana de Digestologia
- Instituto de Salud Carlos III