Trem2 <sup>R47H</sup> and reduced <i>TREM2</i> expression both mimic human Alzheimer’s disease signatures in mice
We demonstrated that Trem2*R47H and Trem2*R47H<sup>HSS</sup> mice are complementary models for the study of molecular contributions to LOAD pathology.
Authors
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Gareth R. Howell (ORCID: https://orcid.org/0000-0003-0565-6474)
- Dylan Garceau
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Bruce T. Lamb (ORCID: https://orcid.org/0000-0001-8507-2561)
- Adrian L. Oblak (ORCID: https://orcid.org/0000-0003-1210-8791)
- Gregory A. Cary (ORCID: https://orcid.org/0000-0003-3573-5229)
- Annat Haber (ORCID: https://orcid.org/0000-0001-8407-9171)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- T. Abel (ORCID: https://orcid.org/0000-0002-6519-6898)
Institutions
- Jackson Laboratory (US)
- Indiana University – Purdue University Indianapolis (US)
- Indiana University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-19
- DOI
- https://doi.org/10.64898/2025.12.17.694758
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00