Molecular and clinical characteristics of patients with non-small cell lung cancer (NSCLC) harboring <i>KRAS</i> G12V mutations
KRAS G12V-mutated NSCLC is characterized by a strong association with tobacco use, high co-mutation rates in clinically relevant genes, and a favorable response to PD-L1-based immunotherapy. The observed mutation landscape supports the potential for dual checkpoint blockade in a significant subset.
Authors
- Jana Fassunke (ORCID: https://orcid.org/0000-0002-8391-5577)
- Reinhard Büttner (ORCID: https://orcid.org/0000-0001-8806-4786)
- Heather Scharpenseel (ORCID: https://orcid.org/0000-0001-6322-8350)
- Rieke Nila Fischer (ORCID: https://orcid.org/0000-0002-9196-1864)
- Juergen Wolf (ORCID: https://orcid.org/0000-0001-8833-8812)
- Carolin Jakob (ORCID: https://orcid.org/0009-0008-5641-6888)
- Sebastian Yves Friedrich Michels (ORCID: https://orcid.org/0000-0003-3164-870X)
- Malte Verheyen (ORCID: https://orcid.org/0009-0008-7552-9044)
- Su Ir Lyu (ORCID: https://orcid.org/0009-0002-4125-6048)
- Alexander Quaas (ORCID: https://orcid.org/0000-0002-3537-6011)
- Matthias Scheffler (ORCID: https://orcid.org/0000-0002-9031-1368)
- Anna Kron (ORCID: https://orcid.org/0000-0002-3047-6486)
- Richard F. Riedel (ORCID: https://orcid.org/0000-0002-8883-1188)
- Lea Ruge (ORCID: https://orcid.org/0000-0003-3390-0411)
- Ullrich Graeven (ORCID: https://orcid.org/0000-0001-6082-7710)
- Sabine Merkelbach‐Bruse (ORCID: https://orcid.org/0000-0002-0312-5760)
- U. Siebolts (ORCID: https://orcid.org/0009-0000-2336-4737)
- Carina Heydt (ORCID: https://orcid.org/0000-0003-3184-9579)
- Michaela Angelika. Ihle (ORCID: https://orcid.org/0009-0007-8948-7116)
- Anna Rasokat (ORCID: https://orcid.org/0009-0008-7850-6374)
- Janna Siemanowski-Hrach (ORCID: https://orcid.org/0009-0000-8453-5229)
- Karl-Josef Franke (ORCID: https://orcid.org/0009-0009-1357-8884)
- Jutta Kappes (ORCID: https://orcid.org/0009-0000-9569-7696)
- Wolfgang Schulte (ORCID: https://orcid.org/0009-0005-0333-6962)
- Felix John (ORCID: https://orcid.org/0000-0002-0616-3391)
Institutions
- TH Köln - University of Applied Sciences (DE)
- Witten/Herdecke University (DE)
- University of Mannheim (DE)
- University of Cologne (DE)
- St. Marien-Hospital Bonn (DE)
- Kliniken Maria Hilf (DE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2581
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00