Broadening the gates: Analysis of potentially modifiable study entry criteria in pancreatic and biliary tract cancer trials
Rigid eligibility criteria exclude stable patients who might benefit from investigational treatments. Easing criteria related to incidental or asymptomatic laboratory abnormalities could broaden trial accessibility and improve enrollment in populations that are more representative of real-world use.
Authors
- Mitesh J. Borad (ORCID: https://orcid.org/0000-0003-2700-2658)
- Robin Kate Kelley (ORCID: https://orcid.org/0000-0002-1984-2430)
- Melinda Bachini (ORCID: https://orcid.org/0000-0001-6850-2929)
- Milind M. Javle (ORCID: https://orcid.org/0000-0001-9158-0941)
- Lipika Goyal (ORCID: https://orcid.org/0000-0002-9777-6221)
- Nilofer S. Azad (ORCID: https://orcid.org/0000-0002-9613-3988)
- Lianchun Xiao (ORCID: https://orcid.org/0000-0003-0972-2766)
- Fen Saj (ORCID: https://orcid.org/0000-0003-0102-1789)
- Lola A. Fashoyin‐Aje (ORCID: https://orcid.org/0000-0001-7328-7813)
- Juan W. Valle (ORCID: https://orcid.org/0000-0002-1999-0863)
- Stacie Lindsey (ORCID: https://orcid.org/0000-0002-1609-4916)
- Shubham Pant (ORCID: https://orcid.org/0000-0001-9281-480X)
- Felicity K. Namayanja
Institutions
- United States Food and Drug Administration (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- University of Manchester (GB)
- Mayo Clinic in Arizona (US)
- Cancer Research UK Manchester Institute (GB)
- Stanford Medicine (US)
- Cholangiocarcinoma Foundation (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1002/cncr.70227
- Citations
- 1
- Primary Topic
- Ethics in Clinical Research
- Type
- article
- Field-Weighted Citation Impact
- 1.88