Test–retest reliability of cognitive fatigability measures during the SDMT and PASAT in people with multiple sclerosis
ObjectiveCognitive capacity tests can measure cognitive fatigability (CF) in persons with multiple sclerosis (pwMS). This study investigated test-retest reliability of CF measures using Paced Auditory Serial Addition Test (PASAT) and Symbol Digit Modalities Test (SDMT).MethodsCF index (CFI%) comparing the last and first thirds and delta scores of SDMT and PASAT were assessed in 49 pwMS (EDSS:3-6.5) and 23 healthy controls. Tests were performed twice 5-7 days apart.ResultsBoth groups showed a performance decline (-2 to -21%). CFI and delta showed poor reliability in both groups (ICC range = 0.04-0.36).ConclusionsCF measures exhibited low reliability in pwMS.
Authors
- Ilse Lamers (ORCID: https://orcid.org/0000-0001-6147-4769)
- Lisa Tedesco Triccas (ORCID: https://orcid.org/0000-0001-9097-9352)
- Zuhal Abasıyanık (ORCID: https://orcid.org/0000-0003-3086-8102)
- Mieke D’hooge (ORCID: https://orcid.org/0000-0002-7973-305X)
- Felipe Balistieri Santinelli (ORCID: https://orcid.org/0000-0002-1164-4018)
- Cintia Ramari (ORCID: https://orcid.org/0000-0002-9405-5437)
- Peter Feys (ORCID: https://orcid.org/0000-0002-5680-5495)
- Daphne Kos (ORCID: https://orcid.org/0000-0003-3566-2269)
Institutions
- National Multiple Sclerosis Society (US)
- King's College London (GB)
- Izmir Kâtip Çelebi University (TR)
- Wockhardt (United States) (US)
- National Hospital for Neurology and Neurosurgery (GB)
- National MS Center Melsbroek
- University College London (GB)
- Hasselt University (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Fatigue Biomedicine Health & Behavior
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1080/21641846.2025.2601487
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00